Peripheral Neuropathy, 4th Edition - 2-Volume Set
By Peter James Dyck, MD and P. K. Thomas, DSc MD FRCP LRCP FRCPath
Approx. 2992 pages, Approx. 700 illustrations, Copyright 2005
Edited by internationally acclaimed experts in the field, this authoritative 2-volume Gold Standard comprehensively covers the neurobiology and diseases of the peripheral nervous system. It encompasses neurobiology, clinical neurophysiology, molecular genetics, and clinical diagnosis and management. The 4th Edition has been rewritten and updated to provide a fresh account of all subjects, with an emphasis on new information about cell biology, genetics, proteomics, clinical manifestations, and new treatments. And, a user-friendly organization allows readers to quickly find specific information, or access more in-depth coverage when needed.
REVIEW OF THE LAST EDITION: “It is a pleasure to find that this landmark monograph in the history of clinical neurology has maintained its position as a text that has been needed and that provides a model for others to imitate. The editors and authors are to be congratulated for a major achievement.”—Mayo Clinic Proceedings
Provides authoritative, in-depth information on neurobiology and diseases of the peripheral nervous system.
Presents complete coverage of development - anatomy - physiology - pharmacology -special testing (nerve conduction and EMG), autonomic testing, and testing of impairment and disability - and the diagnosis, management, and outcomes for peripheral neuropathies.
Includes information on epidemiologic survey and pharmaceutical industry trials, with coverage of the complications of diabetes mellitus and other metabolic diseases
New to this Edition
Features new clinically oriented sections that discuss key areas such as pain management - peripheral neuropathies and cancer - pediatric management issues - new diagnostic techniques
Discusses new developments in molecular genetics, new manifestations of altered immunity, metabolic disease, and course.
Covers the many new treatment and management techniques now available, including strategies for patients with infections, altered immunity, lymphoma and paraneoplastic neuropathies, and metabolic neuropathies.
Includes new coverage of the enteric nervous system, management of gut dysmotility, cutaneous receptors and their function, cutaneous innervation, and quantitative sensation testing.
Table of Contents
1. Introduction - Henry deF. Webster
II. STRUCTURE OF THE PERIPHERAL NERVOUS SYSTEM
2. Gross Anatomy of the PNS – Ernest Gardner & Richard P. Bunge (No change/will use PN3 version) 3. Microscopic Anatomy of the PNS - C.H. Berthold, J. Fraher & R. H. M. King
III. FUNCTION OF THE PERIPHERAL NERVOUS SYSTEM
4. Channel Function in Axons and Sheath Cells –S. Y. Chiu 5. Nerve Excitability Measures: Biophysical Basis and Use in the Investigation of Peripheral Nerve Disease - Matthew C. Kiernan, David Burke & Hugh Bostock 6. The Muscle Spindle - R. W. Banks 7. The Golgi Tendon Organ – J. Scott 8. The Peripheral Sensory Nervous System: Dorsal Root Ganglion Neurons – Sally N. Lawson 9. The Pupil - James J. Corbett 10. 11. Neurologic Control of Cardiac Function - David Paterson & John Coote 12. Neurobiology of Autonomic Peripheral Ganglia - David Kreulen 13. Neurobiology of the Enteric Nervous System - Jackie D. Wood 14. Autonomic and Somatic Systems to the Anorectum and Pelvic Floors – Adil E. Bharucha & Christopher Klingele 15. Autonomic Systems to the Urinary Bladder & Sexual Organs - William C. de Groat & August M. Booth 16. Sympathetic nerves and control of blood vessels to human limbs - Michael J. Joyner, Paul M. VanHoutte, John R. Halliwill & John T. Shepherd
IV. NEUROBIOLOGY OF THE PERIPHERAL NERVE SYSTEM
17. Molecular Signaling in Schwann Cell Development - R. Mirsky & K. Jessen 18. Growth Factors of the PNS - Anthony Windebank 19. Axonal Flow - W. Stephen Brimijoin 20. Myelination – O. Suter & R. Martini 21. The Control of Axonal Caliber - John W. Griffin & Ahmet Hoke 22. Guidance of Axons to Targets in Development and in Disease – Frank Bradke 23. Aging of the PNS – T. Cowen & R.H.M. King 24. Oxidative Stress and Excitatory Neurotoxins - Phillip A. Low 25. Transgenic Models of Nerve Degeneration – R. Martini
V. NEUROIMMUNOLOGY OF THE PERIPHERAL NERVOUS SYSTEM
26. Introduction to Immune Reactions in the PNS - Hans-Peter Hartung, Guido Stoll & Klaus Toyka 27. Peripheral Nerve Antigens - Hugh J. Willison, Norman A. Gregson, Graham M. O’Hanlon & Richard A. C. Hughes 28. Experimental Autoimmune Neuritis (EAN) - Ralf Gold, Guido Stoll, Bernd C. Kieseier, Hans-Peter Hartung & Klaus Toyka 29. Fundamentals of Immune Therapy - J.D. Pollard, Richard Hughes & Peter Hartung
VI. FUNCTIONAL COMPARTMENTS AND NERVE-FIBER ENVIRONMENT
30. The Blood Nerve Barrier – Ananda Weerasuriya 31. Nerve Blood Flow and Nerve Fiber Microenvironment - Phillip McManis & Phillip A. Low
32. Pathology of Peripheral Neuron Cell Bodies - Michale J. Groves & Francesco Scaravilli 33. Pathologic Alterations of Nerves - Peter J. Dyck, P. J. B. Dyck & JaNean Engelstad 34. Pathology of the Neuromuscular Junction - Andrew G. Engel 35. Pathology and Quantitation of Cutaneous Innervation - William R. Kennedy, Justin C. McArthur, Michael J. Polydefkis & Gwen Wendelschafer
VIII. NERVE CONDUCTION AND ELECTROMYOGRAPHY
36. Nerve Conduction and Needle Electromyography - Jun Kimura 37. Nerve Tests Expressed as Percentiles, Normal Deviates and Composite Scores – Peter J. Dyck, Peter C. O’Brien, Jenny Davies, Christopher J. Klein & P. James B. Dyck 38. Single Fiber Electromyography - Erik Stalberg & J. Trontelj 39. Single-unit Recordings of Afferent Human Peripheral Nerves by Microneurography – Erik Torebjork & Martin Schmelz 40. Compound Action Potential of Sural Nerves in Vitro - Edward H. Lambert & Peter J. Dyck(No change/will use PN3 version)
IX. QUANTITATING SYMPTOMS, IMPAIRMENTS AND OUTCOMES
41. Quantitating Neuropathic Symptoms, Impairments and Outcomes – Peter J. Dyck & Richard A. C. Hughes 42. Health Outcomes and Quality of Life - Ann Jakoby 43. Quantitation of Sensory Abnormality - Peter J. Dyck, Peter C. O’Brien, David M. Johnson Christopher J. Klein & P. James B. Dyck 44. Quantitation of Muscle Contraction & Strength - Kenton R. Kaufman 45. Quantitation of Autonomic Impairment - Phillip Low & C.J. Mathias
X. DISEASES OF THE PERIPHERAL NERVOUS SYSTEM
Part A. Differential Diagnoses and Epidemiology 46. Clinical Patterns – Philip Thompson & P. K. Thomas 47. Differential Diagnoses of Polyneuropathy – Ian A. Grant, Timothy J. Benstead & Peter J. Dyck 48. Epidemiologic Approaches to Peripheral Neuropathy - James P. Burke & L. Joseph Melton, III Part B. Diseases of Cranial Nerves 49. Diseases of the Third, Fourth, and Sixth Cranial Nerves - Jacqueline A. Leavitt & Brian R. Younge 50. Diseases of the Fifth Cranial Nerve – Richard A. C. Hughes 51. Diseases of the Seventh Cranial Nerve - Caroline M. Klein 52. Diseases of the Eighth Cranial Nerve - Linda M. Luxon & Doris Bamiou 53. Diseases of the Ninth, Tenth, Eleventh, and Twelfth Cranial Nerves – C. Mathias & P. K. Thomas Part C. Diseases of Spinal Cord, Spinal Roots, and Limb Girdle Plexuses 54. Myelopathies Affecting Anterior Horn Cells and Centrally Directed Afferent Axons in Posterior Horns and Columns – Caroline Klein & Annabel Wang 55. Diseases of Spinal Roots – Colin Chalk 56. Mechanical Compression, Traction, Electrical Radiation and Neoplastic Infiltration of the Brachial Plexus - Asa Wilbourne 57. Diseases of Spinal Cord, Spinal Roots, and Limb-Girdle Plexuses - Michael Donaghy Part D. Neuropathy Due to Compression, Entrapment or Physical Injury 58. Mechanisms of Nerve Injury from Compression, Entrapment, Traction and Ischemia - Ted Burns & Peter J. Dyck 59. Mechanisms of Repair After Traumatic Injury - Susan Hall 60. Median Neuropathy – J. Clarke Stevens 61. Upper Limb Neuropathies: suprascapular, axillary, nerve to serratus anterior, radial and ulnar - Asa Wilbourne 62. Lower Limb Neuropathies – Asa Wilbourne 63. Operating on Peripheral Nerves – Rolfe Birch Part E. Sporadic Motor Neuron Disease 64. Sporadic Motor Neuron Degeneration - Nigel Leigh Part F. Basis of Inherited Disease 65. Mendelian and Mitochondrial Inheritance, Gene Identification, and Clinical Testing - Virginia V. Michels, Stephen N. Thibodeau & Erik C. Thorland 66. Transgenic Models of Inherited Neuropathy - Clare Huxley & Andrea Roberterson Part G. Inherited Motor Neuron Degeneration 67. Transgenic Models of ALS – Eric Sorenson 68. Inherited Motor Neuron Degeneration – Nigel Leigh 69. Hereditary Motor Neuropathies (Spinal Muscular Atrophies) - Peter de Jonghe Part H. Hereditary Motor and Sensory Neuropathies 70. Principles of Classifications, Clinical Syndromes - Michael Shy, Peter J. Dyck, Phillip F. Chance, James R Lupski & Christopher J. Klein 71. Disorders Related to PMP22 Mutations - James R. Lupski & Phillip F. Chance 72. The Hereditary Motor and Sensory Neuropathies (HMSN) 73. Related to MPZ (P0) Mutations – Michael E. Shy 74. Disorders Related to EGR 2 Mutations - Laura E. Warner & James R. Lupski 75. Molecular Genetics of HMSN II (CMT 2)- Christopher J. Klein & Peter J. Dyck 76. Hereditary Brachial Plexus Neuropathy - Christopher J. Klein & Anthony J. Windebank 77. Autosomal Recessive HMSN - Anneke Gabrёёls-Festen & P. K. Thomas 78. X-Linked HMSN – Steve Scherer 79. Multiple Endocrine Neoplasia, Type 2B – J. Aidan Carney Part I. Hereditary Sensory and Autonomic Neuropathies 80. Clinical, Pathologic Classification, and Molecular Genetics - Christopher J. Klein, Robert H. Brown & Peter J. Dyck Part J. Inborn errors of Metabolism With Peripheral Nerve Involvement 81. Lysosomal and Peroxisomal Disorders - P. K. Thomas & Hans Goebel 82. Porphyria - A. J. Windebank 83. Fabry Disease – Roscoe O. Brady & Raphael Schiffmann 84. Tangier Disease and Neuropathy – Mason Freeman & Gilmore O’Neill 85. Hereditary Amyloid Neuropathy – M. Reilly 86. Mitochondrial Disorders – Michael Hanna Part K. Neuropathy Associated with Systemic Disease 87. Diabetic Polyneuropathy - P.K. Thomas, D. Tomlinson & G. Llewelyn 88. Diabetic Radiculoplexus Neuropathies - P. James B. Dyck & J. Clarke Stevens 89. Neuropathies Associated With Renal Failure, Hepatic Disorders, Chronic Respiratory Disease and Critical Illness – Douglas W. Zochodne 90. Neuropathy in Diseases of Thyroid and Pituitary Glands - John Pollard Part L. Nutritional and Vitamin Deficiencies 91. Nutritional and Vitamin Deficiency – David Saperstein & Richard Barohn 92. Myeloneuropathies – Gustavo C. Roman Part M. Infections 93. Leprosy - Thomas D. Sabin, Thomas R. Swift & Robert R. Jacobson 94. Lyme Borreliosis – Gerard Said 95. Herpes Simplex and Zoster - Donald Gilden & Kenneth Tyler 96. Peripheral Neuropathies in HIV Infection - Ahmet Hoke & David R. Cornblath 97. Diphtheritic Polyneuropathy – David Pleasure & Albee Messing 98. Parasitic Infections – Sudha Pottumarthy & Thomas Fritsche Part N. Inflammatory and Immune 99. Antibodies to Nerve Components and Neuropathy - A. Pestronk & Glenn Lopate 100. AIDP – John W. Griffin 101. CIDP – Angelika F. Hahn, Hans-Peter Hartung & Peter J. Dyck 102. Neuropathy Associated with the Monoclonal Antibodies - Robert A. Kyle & Peter J. Dyck 103. Multifocal Motor Neuropathy and Persistent Conduction Block – H. J. Willison & Bruce V. Taylor 104. Brachial Plexus Neuropathy - Guillermo A. Suarez 105. Nonmalignant Inflammatory Sensory Polyganglionopathy - Benn E. Smith, Anthony J. Windebank & Peter J. Dyck 106. Cryptogenic Sensory Polyneuropathy - Ian A. Grant 107. Neuropathies with Systemic Necrotizing Vasculitis - John T. Kissel & Jerry R. Mendell 108. Neuropathies and Microvasculitis – P. James B. Dyck 109. Sarcoid Neuropathy – Gerard Said & Catherine Lacroix Part O. Peripheral Neuropathy Associated with Malignancy, etc. 110. Amyloidosis and Neuropathy - Robert A. Kyle, John J. Kelly & Peter J. Dyck 111. POEMS Syndrome (Osteosclerotic Myeloma)- Angela Dispenzieri & Guillermo A. Suarez & Robert A. Kyle 112. Paraneoplastic Neuropathy – James McLeod & J. Spies 113. Peripheral Neuropathy Associated with Lymphoma, Leukemia and Myeloproliferative Disorders - E. Peter Bosch, Thomas M. Habermann & Ayalew Tefferi Part P. Neuropathy Associated With Industrial Agents, Metals and Drugs 114. Industrial Agents – Alan Berger & Herbert Schaumburg 115. Metal Neuropathy – A.J. Windebank 116. Pharmaceutical Agents – Steve Herskovitz & Herb Schaumberg Part Q. Tumors 117. Peripheral Nerve Tumors – Caterinia Giannini Part R. Management 118. Management with Acute Neuromuscular Disease in the Intensive Care Unit – Eelco Wijdicks 119. Physical Medicine & Rehabilitation – Mary Dombovy 120. Mechanisms and Pharmacologic Management of Neuropathic Pain - Michael C. Rowbotham 121. Management of Autonomic Failure – Phillip A. Low 122. Management of Cardiovascular Failure – Roy L. Freeman 123. Management of Gut Dysmotility - Michael Camilleri & Adil Bharucha 124. Peripheral Neuropathies in Infants and Children - Ted M. Burns, Monique M. Ryan, Basil T. Darras & H. Royden Jones