Molecular Basis of Cancer 2/e
John Mendelsohn, MD, President, The University of Texas M.D. Anderson Cancer Center, Houston, TX
ISBN 0721672914 · Hardback · 700 Pages · 189 Illustrations
W.B. Saunders · Published August 2001
Welcome to the state-of -the-art 2 nd edition of Molecular Basis of Cancer ! This acclaimed reference incorporates the latest advances and newest research, to give you thorough descriptions of everything from the basic mechanisms of malignant cells and molecular abnormalities in common cancers to new approaches for cancer therapy.
You'll find a broad update on new diagnostic tests and therapeutic interventions now being used in clinical trials and practice. Each chapter discusses the clinical implications for treatment while numerous examples of the latest clinical interventions help you understand and assess the products of the biotechnology revolution!
"An outstanding achievement...An excellent review of the current knowledge."
- Journal of the National Cancer Institute
"A clearly written text with many excellent tables, diagrams, illustrations, and photographs...An outstanding reference."
- Modern Pathology
* IMPORTANT new topics, including chemo-prevention, programmed cell death (apoptosis), genetic counselling, tumour-specific vaccines, genetic abnormalities in the origin and progression of cancer, monoclonal antibody therapy, and molecular predictors of prognosis and response to treatment
NEW and revised chapters, covering new basic science knowledge, new approaches to treatment and keeping all information on the cutting-edge of the specialty
ABUNDANT illustrations, most of them new, to clarify and explain difficult concepts.
Section I: Malignant Transformation
Cancer: A Genetic Disorder
Regulation of the Cell Cycle
Programmed Cell Death and Senescence
Progressive Genetic Abnormalities in Human Neoplasia
Tumor Suppressor Genes
Oncogenes and Signal Transduction
Section II: Growth and Spread of Cancer
Growth Factors and Their Receptors in Epithelial Malignancies
Metastasis and Angiogenesis: Molecular Dissection and Novel Applications
Adhesions and Mechanisms
Tumor Angiogenesis and Antiangiogenesis
Section III: Molecular Pathogenesis of Specific Malignancies
Molecular Biology of Non-Hodgkin's Lymphoma and Multiple Myeloma
Molecular Genetics of Acute Lymphoblastic Leukemia
Molecular Biology of Childhood Neoplasms
Molecular Biology of Lung Cancer
Molecular Abnormalities in Colon and Rectal Cancer
Molecular Basis of Breast Cancer