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Cardiac Electrophysiology, 4th Edition - From Cell to Bedside
By Douglas P. Zipes, MD, MACC and Jose Jalife, MD
Approx. 1200 pages, Approx. 500 illustrations, Copyright 2004
ISBN:0721603238
Description
Here’s today’s most authoritative and up-to-date information on basic and clinical electrophysiology. The 4th Edition covers everything from fundamental explanations of currents and channels, through the theoretical and experimental bases of cardiac electrical activity and arrhythmias, to current clinical understandings of arrhythmias and their treatment—and features the most comprehensive updating and revision to date.
New to this Edition
Covers today’s hottest topics, including HCN channels • stretch-activated channels • inward rectifier channels • contraction-excitation feedback • verve sprouting and arrhythmias • mechanisms of atrial fibrillation • mechanisms of ventricular fibrillation • transgenic and knockout models of cardiac arrhythmias • pharmacogenomics and cardiac arrhythmias • Brugada syndrome • and more.
Features the expertise of 57 new contributors; and, existing contributors have revised and updated completely different chapters from previous editions.
Presents 23 new chapters, including Stretch Activated Channels in the Heart · Biophysical Properties of Inward Rectifier Channels • Human Molecular Genetics and the Heart • Human Genetics of Channelopathies · and more.
Includes revised and updated discussions of calcium channels • voltage regulated potassium channels • membrane pumps and exchangers • connexins • homomeric and heteromeric gap junctions • pharmacology of L-type and T-type channels in the heart • mechanisms of AV nodal excitability and propagation • theory of reentry • rotors and spiral waves in two dimensions • electrical remodeling and chronic atrial fibrillation • mechanisms of initiation of ventricular tachyarrhythmias • atrial fibrillation • ventricular tachycardia • long QT syndrome • Torsades de pointes • more!
Table of Contents
PART I: STRUCTURAL AND MOLECULAR BASES OF ION CHANNEL FUNCTION
Chapter 1. Sodium Channels - Eduardo Marban Chapter 2. Cardiac Calcium Channels - Donald M. Bers Chapter 3. Voltage Regulated Potassium Channels - Gavin Y. Oudit, Rafael J. Ramirez and Peter H. Backx Chapter 4: Intracellular Signaling and Regulation of Cardiac Ion Channels - Anant Khositseth, David E. Clapham, and Michael J. Ackerman Chapter 5: Membrane Pumps and Exchangers - Larry V. Hryshko Chapter 6: Sarcoplasmic Reticulum Ion Channels - Gerhard Meissner. Chapter 7: HCN Channels: From Genes to Function - Andreas Ludwig, Juliane Stieber, Sven Moosmang, Stefan Herrmann, Martin Biel, Franz Hofmann Chapter 8: Molecular Organization and Regulation of the Cardiac Gap Junction Channel Connexin43 - Mario Delmar , Heather S. Duffy, Paul Sorgen, Steven M. Taffet, David C. Spray
PART II: BIOPHYSICS OF CARDIAC ION CHANNEL FUNCTION
Chapter 9: Biophysics of Normal and Abnormal Cardiac Sodium Channel Function - Jeffrey R. Balser Chapter 10: Gating of Cardiac Delayed Rectifier K+ Channels - Michael C. Sanguinetti and Martin Tristani-Firouzi Chapter 11: Heart Mechanoelectric Transduction - Frederick Sachs Chapter 12: Pacemaker Channels and Normal Automaticity - Dario DiFrancesco Chapter 13: Biophysical Properties of Inward Rectifier Potassium Channels - Justus Anumonwo Chapter 14: Homomeric and Heteromeric Gap Junctions - Volodya Hayrapetyan, Guoqiang Zhong, Agustín D. Martínez and Eric C. Beyer. Alonso P. Moreno
PART III: INTERMOLECULAR INTERACTIONS AND PHARMACOLOGY OF CARDIAC ION CHANNELS
Chapter 15: Pharmacology of the Cardiac Na Channel - Jonathan C. Makielski, Bin Ye, Timothy J. Kamp, and Craig T. January Chapter 16: Pharmacology of L-type and T-type channels in the heart - Xiongwen Chen and Steven R. Houser Chapter 17: KCNQ1/KCNE1 Macromolecular Signaling Complex: Channel Microdomains and Human Disease - Sheila Carrol, Junko Kurokawa, and R.S. Kass Chapter 18: Drug-induced Channelopathies - Charlie Antzelevitch Chapter 19: Prospects for Pharmacological Targeting of Gap Junction Channels - Miduturu Srinivas, Heather Duffy, Mario Delmar, David C. Spray
PART IV: ION CHANNELS AND CELLULAR ELECTROPHYSIOLOGY
Chapter 20: Heterogeneous expression of Potassium channels - Jeanne M. Nerbonne Chapter 21: Gap Junction Distribution and Regulation in the Heart - Jeffrey E. Saffitz, Deborah L. Lerner, Kathryn A. Yamada Chapter 22: Cellular Mechanisms of Sinoatrial Activity - Itsuo Kodama, Haruo Honjo, Halina Dobrzynski, Mark R. Boyett Chapter 23: Mechanisms of AV nodal Excitability and Propagation - Igor R. Efimov and Vladimir P. Nikolsk Chapter 24: Intercellular Communication and Impulse Propagation - André G. Kléber Chapter 25: Cardiac tissue architecture Determines speed and safety of propagation - Stephan Rohr and Jan P. Kucera Chapter 26: Restitution, Repolarization and Alternans as Arrhythmogenic Substrate - Kenneth R. Laurita, Ph.D. and David S. Rosenbaum, M.D. Chapter 27: Mechanoelectric Transduction/Feedback: Prevalence and Pathophysiology - Max J. Lab
PART V: MODELS OF CARDIAC EXCITATION
Chapter 28: Ionic mechanisms of cardiac electrical activity: A Theoretical Approach - Yoram Rudy Chapter 29: Two-dimensional propagation in cardiac muscle - Bradley Roth Chapter 30: Three-dimensional Propagation in Mathematical Models - Craig S. Henriquez, Joseph V. Tranquello, David Weinstein, Edward Hsu, Christopher R. Johnson Chapter 31: Modeling Cardiac Defibrillation – Natalia Trayanova
PART VI: NEURAL CONTROL OF CARDIAC ELECTRICAL ACTIVITY
Chapter 32: Molecular and cellular bases of β- and ą-adrenergic modulation of cardiac rhythm - Susan F. Steinberg, Richard B. Robinson, Michael R. Rosen Chapter 33: Nerve Sprouting and Cardiac Arrhythmias. - Lan S. Chen, Peng-Sheng Chen Chapter 34: Cholinergic Atrial Fibrillation - Leonid V. Rosenshtraukh, Vadim V. Fedorov, Oleg F. Sharifov
PART VII: NONLINEAR DYNAMICS, SPIRALS AND HEART RHYTHMS
Chapter 35: Theory of reentry - Marcel Wellner and Omer Berenfeld Chapter 36: Nonlinear Dynamics of Excitation and Propagation in Cardiac Muscle - Zhilin Qu, Alan Garfinkel Chapter 37: Rotors and Spiral Waves in Two Dimensions - Leslie Tung, Nenad Bursac, Felipe Aguel Chapter 38: Scroll waves in three dimensions - Arkady M. Pertsov
PART VIII: ARRHYTHMIA MECHANISMS
Chapter 39: Electrophysiology of the Pulmonary Veins: Mechanisms of initiation of atrial fibrillation - Jeffrey E. Olgin Chapter 40: Mechanisms of Maintenance of Atrial Fibrillation - Omer Berenfeld Chapter 41: Electrical Remodeling and Chronic Atrial Fibrillation - David R. VanWagoner Chapter 42: Mechanisms of Initiation of Ventricular Tachyarrhythmias - Jiashin Wu, Jianyi Wu, and Douglas P. Zipes Chapter 43: Dynamics and Molecular Mechanisms of Ventricular Fibrillation in Normal Hearts - José Jalife Chapter 44: Mechanisms of ventricular fibrillation in the ischemic heart - Alexey Zaitsev Chapter 45: Cellular mechanisms of defibrillation - Vladimir G. Fast Chapter 46: Global mechanisms of defibrillation - Richard A.Gray Chapter 47: Defibrillation Waveforms - Raymond E. Ideker, Joan Huang, Gregory Walcott
PART IX: MOLECULAR GENETICS AND PHARMACOGENOMICS
Chapter 48: Mouse Models of Cardiac Arrhythmias - Barry London Chapter 49: Human molecular Genetics and the Heart - Jeffrey A. Towbin, Neil Bowles Chapter 50: Genetics of Long QT, Brugada and other channelopathies. - Silvia G. Priori, Ilaria Rivolta, Carlo Napolitano Chapter 51: Pharmacogenomics of Cardiac Arrhythmias and Impact on Drug Therapy - Dan M. Roden
PART X: CLINICAL ARRHYTHMIAS MECHANISMS, FEATURES AND MANAGEMENT
SUPRAVENTRICULAR ARRHYTHMIAS
Chapter 52: Sinus rhythm abnormalities - David J. Callans and David J. Lin Chapter 53: Atrioventricular Block And Atrioventricular Dissociation - David Schwartzman Chapter 54: Atrial Flutter: Mechanisms, Clinical Features and Management - Albert L. Waldo Chapter 55: Atrial tachycardia - Kenneth A. Ellenbogen and Mark A. Wood Chapter 56: Atrial fibrillation - Stanley Nattel and Joachim R. Ehrlich Chapter 57: Junctional Rhythms and Tachycardia - Hakan Oral and S. Adam Strickberger Chapter 58: Atrioventricular reentry and variants - Bradley P. Knight and Fred Morady Chapter 59: Electrophysiological Characteristics of Atrioventricular Nodal Reentrant Tachycardia: Implications for the Reentrant Circuits - Deborah Lockwood, Kenichiro Otomo, Zulu Wang, Sara Forresti, Hiroshi Nakagawa, Karen Beckman, Benjamin J Scherlag, Eugene Patterson, Ralph Lazzara, and Warren M. Jackman Chapter 60: Atrial arrhythmias in congenital heart disease - John K. Triedman
VENTRICULAR TACHYCARDIAS
Chapter 61: Ventricular tachycardia in patients with coronary artery disease - David J. Callans, Mark E. Josephson Chapter 62: Ventricular Tachycardia in Patients with Dilated Cardiomyopathy - Joseph M. Galvin and Jeremy N. Ruskin Chapter 63: Ventricular tachycardia in arrhythmogenic right ventricular cardiomyopathy - Guy Fontaine, Paul Fornes, Jean-Louis Hebert, Catherine Prost-Squarcioni, Xavier Jouven, Jean-Sebastian Hulot, Robert Frank, Daniel Thomas Chapter 64: Ventricular tachycardia in hypertrophic cardiomyopathy - Barry J. Maron Chapter 65: Ventricular Tachycardia In Patients With Hypertrophy And Heart Failure - Marc A. Vos, Harry J. Crijns, MD Chapter 66: Ventricular tachycardia in patients following surgery for congenital heart disease - George F. Van Hare Chapter 67: Brugada Syndrome - Josep Brugada, Pedro Brugada, Ramon Brugada, Charles Antzelvitch, Jeffrey Towbin Chapter 68: Catecholaminergic Polymorphic ventricular tachycardia and short-coupled Torsades de Pointes - Carlo Napolitano and Silvia G. Priori Chapter 69: Arrhythmias in Patients with Neurological Disorders - William J. Groh Chapter 70: Long QT syndrome – Phenotype-Genotype Considerations - Peter J Schwartz and Silvia G Priori Chapter 71: Long QT Syndrome – Therapeutic Considerations - Arthur J. Moss, Wojciech Zareba Chapter 72: Ventricular tachycardia in patients with structurally normal hearts - Bruce B. Lerman, Kenneth M. Stein, Steven M. Markowitz, Suneet Mittal, Sei Iwai Chapter 73: Bundle branch reentry - Emile Daoud Chapter 74: Torsades De Pointes - Nabil El-Sherif and Gioia Turitto Chapter 75: Accelerated Idioventricular Rhythm, Bi-directional Ventricular Tachycardia - Wolfram Grimm and Francis E. Marchlinski Chapter 76: Ventricular fibrillation - Andrew Epstein Chapter 77: Prolonged Repolarization And Sudden Infant Death Syndrome - Peter J. Schwartz and Marco Stramba - Badiale Chapter 78: Sudden cardiac death - Robert J. Myerburg, Alberto Interian Jr., Jeffery Simmons, Agustin Castellanos
PART XI: ELECTROCARDIOGRAPHIC RECOGNITION
Chapter 79: Exit block, supernormal conduction, concealed conduction - Michael J. Kilborn and Mark A. McGuire Chapter 80: Parasystole - Augustin Castellanos, Nadir Saoudi, Federico Moleiro, Robert J. Myerburg Chapter 81: Differential Diagnoisis of Wide QRS Complex Tachycardia - John M. Miller, Mithilesh K. Das, Rishi Arora, Cesar Alberte-Lista, Jianyi Wu
PART XII: DIAGNOSTIC EVALUATION
Chapter 82: Assessment of the patient with a cardiac arrhythmia - Douglas P. Zipes and William M. Miles Chapter 83: Exercise-induced cardiac arrhythmias - Ruey Sung, Chi Tai Kuo, Wen Ter Lai Chapter 84: Use of Long?Term (Holter) Electrocardiographic Recordings - Harold L. Kennedy Chapter 85: Use of implantable loop recordings - Andrew Krahn, George J. Klein, Allan C. Skaines, Raymond Yee Chapter 86: High-resolution electrocardiography - Edward J. Berbari Chapter 87: Body surface potential mapping - Bruno Taccardi, Bonnie B. Punske, Nora Eceles Harrison Chapter 88: Head-up tilt table testing - David G. Benditt, Cengiz Ermis, Fei Lü Chapter 89: Heart Rate Variability and Baroreflex Sensitivity - Marek Malik Chapter 90: Monophasic action potential recording - Michael R. Franz Chapter 91: T wave alternans - Stefan H. Hohnloser Chapter 92: Neurocardiac imaging - Gary D. Hutchins, Michael A. Miller and Douglas P. Zipes Chapter 93: Mapping - Vias Markides, Oliver R. Segal, Fernando Tondato, Nicholas Peters
PART XIII: CLINICAL SYNDROMES: RECOGNITION, CLINICAL COURSE, AND MANAGEMENT
Chapter 94: Wolff-Parkinson-White Syndrome - Eric Prystowsky, Raymond Yee, George J. Klein Chapter 95: Sinus Node Dysfunction - Michael Sweeney Chapter 96: Syncope - Hugh Calkins Chapter 97: Results of clinical trials on atrial fibrillation -D. George Wyse Chapter 98: Results of clinical trials of AEDs and ICDs in Patients at Risk for Sudden Death on ventricular arrhythmias with AEDs and ICDs - Alfred Buxton
PART XIV: THERAPY
PHARMACOLOGICAL
Chapter 99: Class I antiarrhythmic drugs: quinidine, procainamide, disopyramide, lidocaine, mexiletine, flecainide, propafenone - Anne Gillis Chapter 100: Beta-blockers and calcium channel blockers - Bramah Singh Chapter 101: Class III Antiarrhythmiac Drugs: Amiodarone, Ibutilide and Sotalol - Timothy W. Smith, Michael E. Cain Chapter 102: Adenosine and digoxin - John DiMarco Chapter 103: Impact of non-traditional antiarrhythmic drugs on sudden cardiac death - Jeffrey Goldberger, Kenneth Weinberg, Alan Kadish Chapter 104: New antiarrhythmic drugs - N A Mark Estes III
ELECTRICAL
Chapter 105: Transthoracic cardioversion and defibrillation - Richard E. Kerber Chapter 106: Implantable cardioverter defibrillators: Technical aspects - Bruce L. Wilkoff Chapter 107: Implantable cardioverter defibrillators: Clinical aspects - Charles Swerdlow and Kalyanam Shiukumar Chapter 108: Implantable atrial defibrillator for atrial fibrillation - Sam Levy Chapter 109: Implantable Pacemakers - David L. Hayes Chapter 110: Newer Applications of Pacemakers - Michael R Gold, MD, PhD and Robert W Peters MD Chapter 111: Biophysics and pathophysiology of lesion formation during radiofrequency catheter ablation - David E. Haines Chapter 112: Focal catheter ablation for atrial fibrillation - Michel Haïssaguerre, Prashanthan Sanders, Pierre Jaïs, Mélèze Hocini, Dipen C. Shah, Jacques Clèmenty Chapter 113: Pulmonary vein isolation for atrial fibrillation - Carlo Pappone and Salvatore Rosanio Chapter 114: Catheter ablation of atrial flutter - Hans Kottkamp and Gerhara Hindricks Chapter 115: Catheter Ablation of Atrial Tachycardia - Chin-Feng Tsai, Ching-tai Tai, Shih-Ann Chen Chapter 116: Catheter Ablation of Atrioventricular Nodal Reentrant Tachycardia - Jonathan M. Kalman Chapter 117: Catheter Ablation of Atrioventricular Reentry - Sabie Ernst, Feifan Ouyang, Matthias Antz, Ricardo Cappato, Karl Heinz Kuck Chapter 118: Catheter ablation of ventricular tachycardia - William Stevenson and Kyoko Soejima Chapter 119: Catheter ablation in pediatric patients - John D. Kugler Chapter 120: Surgery for cardiac arrhythmias - Pierre L. Page
Author Information
By Douglas P. Zipes, MD, MACC, Distinguished Professor of Medicine, Pharmacology, and Toxicology; Director, Division of Cardiology and the Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, IN; and Jose Jalife, MD, Director, Institute for Cardiovascular Research; Professor and Chair, Department of Pharmacology, Professor of Medicine and Pediatrics, SUNY Health Science Center at Syracuse, Syracuse, NY
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