By Gregory Y. H. Lip and John E. Hall, PhD
Trim size 8 1/2 X 10 7/8 in
Here is today's most in-depth reference for any cardiologist, internist, or nephrologist interested in hypertension. Drawing from international experience in cardiology, physiology, and nephrology, Drs. Lip and Hall have assembled a group of section editors and contributors second to none. You'll find the long-term effects of primary and secondary hypertension and a lengthy section on hypertensions for special populations featured prominently. Prevention and treatment of hypertension are covered in detail, from lifestyle and diet issues to drug choice and delivery, and the section on comparison of guidelines is unique to this book.
Find comprehensive coverage of hypertension including pathogenesis, prevention, and treatment all in one practical volume.
See the complete systemic problems of hypertension at a glance with detailed, full-color illustrations of cellular and clinical manifestations.
Simplify navigating the complexities of hypertension using algorithms for clinical exam and diagnosis.
Get specific insight into prevention and treatment of hypertension in special populations.
Go global with a comprehensive section on worldwide guidelines and the application of clinical material to local standards of practice.
Table of Contents
SECTION 1 - EPIDEMIOLOGY
*Blood pressure in Westernized populations *Low blood pressure populations, the impact of rural -urban migration *Regional differences in blood pressure in developed countries *Low blood pressure populations, the impact of rural -urban migration *Fetal influences on blood pressure: the Barker hypothesis *Blood pressure and the risks of cardiovascular disease and stroke
SECTION 2 - PATHOGENESIS OF HYPERTENSION - HEMODYNAMICS AND VASCULAR MECHANISMS
*Haemodynamics of essential hypertension *Genetic models of hypertension *Experimental models of hypertension *Left ventricular physiology in hypertension *The arterial system in human hypertension *Resistance vessels in hypertension *Endothelial function *Vascular growth, angiogenesis and hypertension *Vascular smooth muscle *Cell membranes - vascular smooth muscle action transport - vascular smooth muscle regulation by calcium magnesium and potassium *Coagulation and platelet abnormalities *Cytokines and inflammation
SECTION 3 - PATHOGENESIS OF HYPERTENSION - RENAL AND NEUROHUMORAL MECHANISMS
*Role of the kidney *Autonomic control and hemodynamics of hypertension, baroreceptor function and reflexes *Central nervous control of blood pressure *The Renin-Angiotensin System *Aldosterone and other adrenal steroids *The endothelins *Nitric oxide *Reactive oxygen species and oxidative stress *The natriuretic peptides *Other peptide and related systems *Other peptide and related systems *Eicosanoids *The kallikrein-kinin systems *Sex steroids - estrogens and testosterone
SECTION 4 - PATHOGENESIS OF HYPERTENSION - GENETICS AND LIFESTYLE
*Genetic approaches to hypertension: relevance to human hypertension *Monogenic forms of human hypertension *Potential role of gene therapy in treating hypertension and cardiovascular disease *Lifestyle and blood pressure *Obesity *Dietary fats and blood pressure *Vegetarian diets, protein and fiber *Exercise *Electrolye intake and human hypertension *Alcohol intake and blood pressure *Psychosocial stress and hypertension
SECTION 5 - TARGET ORGAN DAMAGE
*The effects of hypertension on the structure of human resistance vessels *Pathogenesis of atheroma *The brain in hypertension *The kidney in hypertension *The heart in hypertension *The eye in hypertension *Aortic dissection
SECTION 6 - SPECIAL GROUPS
*Hypertension in children *Hypertension in the elderly *Hypertension in pregnancy *Hypertension, Insulin resistance and diabetes *Hypertension in renal failure *Hypertension in ethnic subgroups *Renin subgroups in hypertension *Hyperadrenergic and 'labile' hypertension *Resistant hypertension *Perioperative hypertension, preparing the *Hypertensive patient for anesthesia and surgery *Hypertension in the setting of acute myocardial infarction and percutaneous interventions *Hypertension in patients with concomitant stroke *Hypertension in patients with concomitant cardiac disorders, eg. heart failure, atrial fibrillation, etc *Hypertensive urgencies and emergencies
SECTION 7 - SECONDARY HYPERTENSION
*Renal and renovascular hypertension *Renin-secreting tumors *Primary aldosteronism and other forms of mineralocorticoid hypertension *Cushing's Syndrome and hypertension *Oral contraceptives, Hormone Replacement Therapy and hypertension *Drug-induced hypertension *Phaeochromocytoma *Endocrine hypertension: Thyroid disease and acromegagly *Coarctation of the Aorta *Hypertension and central nervous system *Sleep apnea and hypertension
SECTION 8 - CLINICAL ASSESSMENT AND INVESTIGATIONS
*Overview of assessment and investigation of the hypertensive patient *Blood pressure measurement *Clinical assessment and examination of the hypertensive patient *Ambulatory Blood Pressure Monitoring *ECGs, echocardiography, exercise testing, other cardiological investigations
SECTION 9 - DRUG TREATMENT
*Diuretics *Beta-blockers *Calcium antagonists *ACE inhibitors *Angiotensin Receptor Blockers *Alpha-adrenoceptor antagonists *Vasodilators *Renin inhibitors and Neutral Endopeptidase *Inhibitors *Centrally acting drugs *Combination therapy in the treatment of hypertension *Interactions between antihypertensive drugs and other medications *Lipid-lowering therapy *Antithrombotic therapy *The target blood pressure when treating hypertension *Compliance, quality of life, cost-effectiveness
SECTION 10 - NON PHARMACOLOGICAL TREATMENT
*Non-pharmacological management of hypertension *Multidisciplinary management of hypertension, role of the nurse
SECTION 11 - GUIDELINES
*Guidelines for treating hypertension *Guidelines for treating hypertension - An overview, Europe and Australia *Guidelines for treating hypertension - An overview, D: Third World