Cellular and Molecular Neurophysiology, 3rd Edition
By Constance Hammond
416 pages 336 ills
Trim size 8 1/2 X 11 in
80% new or updated material
Fifteen appendices describing neurobiological techniques are interspersed in the text
Now in full color throughout, with more than 400 carefully selected and constructed illustrations
Provides an instructor website with all the images in electronic format, plus additional material
Basic Neurochemistry, 7th Edition : Molecular, Cellular and Medical Aspects
From Molecules to Networks : An Introduction to Cellular and Molecular Neuroscience
Development of the Nervous System, 2nd Edition
This third edition is the new, thoroughly revised edition of the only current, established and authoritative text focusing on the cellular and molecular physiology of nerve cells. Previously titled Cellular and Molecular Neurobiology, the new title better reflects this focus. The book is hypothesis driven rather than just presenting the facts, and the content is firmly based on numerous experiments performed by the top experts in the field. While the book does cover the important facts, it also presents the background for how researchers arrived at this knowledge to provide a context for the field. It teaches not only how excitable cells work in detail, but also how to construct and conduct intelligent research experiments. This book promotes a real understanding of the function of nerve cells that is useful for practicing neurophysiologists and students in a graduate-level course on the topic alike.
Neurophysiologists, neurobiologists, neurologists, as well as graduate-level courses on neurophysiology.
"In its third internationally acclaimed edition, this textbook provides an unrivaled account of the basic foundations of molecular and cellular neurophysiology. For those of us who were inclined to believe that the unprecedented development of neuroscience made neurophysiology disposable, Constance Hammond proves us with conviction and elegance that this is just not the case!" -Dr. Robert Dantzer, Professor of Psychoneuroimmunology, Integrative Immunology and Behavior Program University of Illinois at Urbana-Champaign
"Unlike many other texts, chapters in this book are structured around the known neurophysiological facts. The author states the fact, gives simple explanations for why it is so, and when appropriate follows her discussion by in-depth analyses. Also unlike many other texts, the chapters are not built around the work of other people, and are not overburdened with references to published material. This style makes for a very fluid and self consistent read which should be of interest to neophytes and advanced students alike." -Jean-Marc Fellous, Professor Psychology, Neuroscience, Cognitive Sciences, and Applied Mathematics, University of Arizona, Tucson
"A particularly strong feature of the book is that most of the exposition is driven by data from original experiments, supplying many figures that offer a ready-made basis for lectures (figures are available on the instructor's website). In addition, appendices of many chapters provide further information about techniques or related topics (e.g. patch-clamping, fluorescence measurements, neurotransmitter identification) that is often not essential to understanding the physiology, but is extremely useful to the more interested or advanced student." -Jim Belanger, Department of Biology, West Virginia University
"More than any similar volume that I have come across in recent years, this one has the potential of luring students of neuroscience and even students from other fields to build a career in neurophysiology." -György Buzsáki, M.D., Ph.D., Board of Governors Professor, Center for Molecular and Behavioral Neuroscience, Rutgers University
"Constance Hammond has rewritten and updated most of the chapters, which gives a better homogeneity to the book. The figures are now in color and thereby easier to read. In summary, this book is a very precious and unique tool, ideal for students with a strong interest in neuroscience." -Jean-Francois Perrier, Institute of Neuroscience and Pharmacology, University of Copenhagen, Denmark
"This is an outstanding book that I will definitely recommend to my students." -Peter Somogyi, Oxford University, United Kingdom
Part I – Neurons: Excitable and Secretory Cells that Establish Synapses.
Chapter 1: Neurons
Chapter 2: Neuron –Glial Cell Cooperation
Chapter 3: Ionic Gradients, Membrane Potential and Ionic Currents Appendix 3.1: The active transport of ions by pumps and transporters maintain the unequal distribution of ions Appendix 3.2: The passive diffusion of ions through an open channel Appendix 3.3: The Nernst equation
Chapter 4: The Voltage-Gated Channels of Na+ Action Potentials Appendix 4.1: Current clamp recording Appendix 4.2: Voltage clamp recording
Chapter 5: The Voltage-Gated Channels of Ca+2Action Potentials: Generalization Appendix 5.1: Fluorescence measures of intracellular Ca2+ concentration Appendix 5.2: Tail currents
Chapter 6: The Chemical Synapses Appendix 6.1: Neurotransmitters, agonists and antagonists Appendix 6.2: Identification and Localization of Neurotransmitters and their Receptors
Chapter 7: Neurotransmitter Release Appendix 7.1: Quantal nature of neurotransmitter release Appendix 7.2: The probabilistic nature of neurotransmitter release (the neuromuscular junction as a model) Part 2 – Ionotropic and Metabotropic Receptors in Synaptic Transmission and Sensory Transduction.
Chapter 8: The Ionotropic Nicotinic Acetycholine Receptors Appendix 8.1: The neuronal nicotinic receptors
Chapter 9: The Ionotropic GABAA Receptor Appendix 9.1: Mean time and mean burst duration of the GABAA single-channel current Appendix 9.2: Non-invasive measurements of membrane potential and of the reversal potential of the GABAA current using cell-attached recordings of single channels
Chapter 10: The Ionotropic Glutamate Receptors
Chapter 11: The Metabotropic GABAB Receptors
Chapter 12: The Metabotropic Glutamate Receptors Part 3 – Somato-Dendritic Processing and Plasticity of Postsynaptic Potentials.
Chapter 13: Somato-Dendritic Processing of Postsynaptic Potentials I: Passive Properties of Dendrites
Chapter 14: Subliminal Voltage-Gated Currents of the Somato-Dendritic Membrane
Chapter 15: Somato-Dendritic Processing of Postsynaptic Potentials II: Role of Subliminal Depolarizing Voltage-Gated Currents
Chapter 16: Somato-Dendritic Processing of Postsynaptic Potentials III: Role of High Voltage-Activated Depolarizing Currents
Chapter 17: Firing Patterns of Neurons
Chapter 18: Synaptic Plasticity Appendix 18.1: Depolarization of induced suppression of inhibition (DSI) Part 4 – The Adult Hippocampal Network.
Chapter 19: The Adult Hippocampal network
Chapter 20: Maturation of the Hippocampal Network