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Clinical Trials in Psychiatry, 2nd Edition
-精神科
- 編號: 0-000000009780470513026
- 作者:Brian Everitt
- 原價-2500    - (熱賣價)2000      - 節省 ↓20%
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- 內容介紹
Clinical Trials in Psychiatry, 2nd Edition
Brian Everitt, Simon Wessely
ISBN: 978-0-470-51302-6
Hardcover
248 pages
March 2008
At last – a new edition of the highly claimed book Clinical Trials in Psychiatry
This book provides a concise but thorough overview of clinical trials in psychiatry, invaluable to those seeking solutions to numerous problems relating to design, methodology and analysis of such trials. Practical examples and applications are used to ground theory whenever possible. The Second Edition includes new information regarding:

Recent important psychiatric trials
More specific discussion of psychiatry in the USA and the particular problems of trials in the USA, including comments about the FDA (U.S. Food and Drug Administration)
An extended chapter on meta-analysis
Further discussion of sub-group analysis
Special features include appendices outlining how to design and report clinical trials, what websites and software programs are appropriate and an extensive reference section.

From the reviews of the First Edition:

“Everitt & Wessely are to be congratulated on producing an excellent guide to help overcome the snags in clinical trial research. Clearly written and in an engrossing style, the book is likely to become a classic textbook on clinical trials, and not just in psychiatry. The authors’ enthusiasm and grasp of clinical trial research make for a gripping and insightful read…it is one of the very best books that has been written on clinical trials.” THE BRITISH JOURNAL OF PSYCHIATRY

"The experience of both authors in this area gives the book a very pragmatic approach grounded in reality, with theoretical overviews invariably being followed by practical examples and applications… an invaluable companion to anyone involved in, or contemplating undertaking, clinical trials research.” PSYCHOLOGICAL MEDICINE

Preface to the first edition
Preface to the second edition

1. Treatments, good, bad or worthless – and how do we tell?

Treatments worthless – and worse

A brief history of treating the mentally ill

Summary


2. The randomized clinical trial

Introduction

The clinical trial

Ethical issues in clinical trials

Informed consent

Compliance

Summary

3. Design issues in clinical trials

Introduction

Clinical trial designs

Methods of randomization

Methods of masking treatments

The size of a clinical trial

Interim analysis

Summary

4. Special problems of trials in psychiatry

Introduction

Explanatory versus pragmatic trials

Complex interventions

Outcome measures in psychiatry

Summary

5. Some statistical issues in the analysis of psychiatric trials

Introduction

P-values and confidence intervals

Using baseline data

Longitudinal data

Missing values and dropouts in longitudinal data

Multiple outcome measures

Intention-to-treat

Economic evaluation of trials

Number needed to treat

6. Analysing data from a psychiatric trial: an example

Introduction

Beating the Blues

Analysis of the post-treatment BDI scores

Graphical displays and summary measure analysis of longitudinal data

Random effects models for the BtB data

The dropout problem in the BtB data

Summary

7. Systematic reviews and meta-analysis

Introduction

Study selection

Publication bias

The statistics of meta-analysis

Some examples of meta-analysis of psychiatric trials

Summary

8. RCTs in psychiatry: threats, challenges and the future

Introduction

Can randomized clinical trials in psychiatry be justified?

Are randomized clinical trials really necessary?

Conflicts of interest

Scandals, trials and tribulations

The future of psychiatric trials

Defending the clinical trial

Summary


Appendix A Issues in the management of clinical trials- 'how to do it'

Introduction

Clinical trial protocols

Getting the costs right

Collecting and managing the data

Writing the patient information sheet

Getting informed consent

Maintaining recruitment

Useful web sites

Appendix B Writing a trial report

Introduction


Appendix C Useful software for clinical trials

Introduction

Data management

Design

Analysis

Bibliography

Index



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