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Retina, 4th Edition - 3-Volume Set
By Stephen J. Ryan, MD, David R. Hinton, MD, FRCPC, Andrew P. Schachat, MD and Pat Wilkinson, MD
3104 pages, 3400 ills,
Trim size 8 5/8 X 10 7/8 in,
Praised by JAMA as "The most complete description of the development, structure, function, pathophysiology, and treatment of the retina and its diseases to be found anywhere," this monumental three-volume work puts all of today's scientific and clinical knowledge of the retina at readers' fingertips. The New Edition has been comprehensively updated and reorganized to reflect all of the very latest scientific and genetic discoveries, diagnostic imaging methods, drug therapies, treatment recommendations, and surgical techniques. The result is an indispensable reference and diagnostic tool for generalists and specialists alike.
Also available as a multimedia e-dition! See Companion Products for more information.
Delivers the editorial expertise of four highly respected authorities, as well as contributions from internationally recognized leaders in visual science, ophthalmology, and vitreoretinal studies.
Presents more than 3,400 superb illustrations (2,200 in full color) that capture all forms of retinal disease from every perspective.
New to this Edition
Offers the very latest information on the genetic basis of retinal disease, diagnostic retinal imaging, photodynamic therapy, and age-related macular degeneration.
Examines the most recent advances in diagnostic indocyanine green angiography • optical coherence tomography (OCT) and quantitative fluoroscein angiography • macular translocation with 360° peripheral retinectomy • surgery for diffuse macular edema due to multiple causes, including proliferative vitreoretinopathy • artificial vision • and much more.
Features a completely restructured section on age-related macular degeneration that includes epidemiology and risk factors • prophylaxis and prevention knowledge gained from large clinical trials like AREDS • proven and experimental treatments for AMD • and pharmacotherapy.
Incorporates a multitude of new full-color images, 2200 in all.
Also available as a multi-media e-dition containing value-added features such as a searchable, downloadable electronic image library and video clips of procedures.
Table of Contents
Part 1 Basic Science, Inherited Retinal Disease and Tumors
Section 1 Anatomy and Physiology
1. The development of the retina - Thomas Reh and Ala Moshiri 2. Stem Cells - Martin Friedlander 3. The choroid: structural considerations - David R. Guyer, Andrew P. Schachat and W. Richard Green 4. Functional anatomy of the mammalian retina - Stephen C. Massey 5. Retinal and choroidal blood flow in health and disease - Alon Harris, David Bingaman, Thomas Ciulla and Bruce Martin 6. Electrogenesis of the electroretinogram - Laura J. Frishman 7. Cell biology of the retinal pigment epithelium - Gabriele Thumann, Stephan Hoffman and David R. Hinton 8. Structure and function of rod photoreceptors - Jeannie Chen, Scott Geller and John Flannery 9. The physiology and morphology of the vertebrate retina - Robert F. Miller
Section 2 Visual Psychophysics
10. Color vision and night vision - Joel Pokorny and Vivianne C. Smith 11. Visual acuity and contrast sensitivity - Gary S. Rubin 12. Visual fields in retinal disease - Steven E. Feldon
Section 3 Ocular Immunology
13. Retinal autoimmunity - Wee-Kiak Lim and Robert B. Nussenblatt
Section 4 Evaluation
14. Diagnostic ophthalmic ultrasound - Ronald L. Green and Sandra Frazier Byrne 15. Clinical Electrophysiology - Thomas E. Ogden
Section 5 Genetics
16. Molecular Genetics of Retinal Disease - Jeremiah Brown, Andrew R. Webster, Val C. Sheffield and Edwin M. Stone
Section 6 Retinal Degenerations and Dystrophies
17. Retinitis pigmentosa and allied disorders - Richard G. Weleber and Kevin Gregory-Evans 18. Hereditary choroidal disease - Diana V. Do, Kang Zhang, Daniel C. Garabaldi, Ronald E. Carr and Janet S. Sunness 19. Abnormalities of cone and rod function - Janet Sunness 20. Hereditary vitreoretinal degenerations - Albert O. Edwards and Joseph E. Robertson, Jr.
Section 7 Principles of Vitreoretinal Therapy
21. Retinal Laser Therapy: Biophysical Basis and Applications - Daniel Palanker, Mark S. Blumenkranz and John J. Weiter
Part 2 Tumors of the Retina, Choroid, and Vitreous
Section 1 Tumors of the Retina
22. Retinoblastoma - A. Linn Murphree, Michael A. Samuel and J. William Harbour 23. Cavernous hemangioma - Anita Agarwal, Thomas Aaberg and Paul Sternberg 24. Capillary hemangioma of the retina and von Hippel-Lindau disease - Brad J. Hinz and Andrew P. Schachat 25. Tuberous sclerosis and the eye - Alan F. Cruess and Sanjay Sharma 26. Other phakomatoses - Jerry Shields and Carol Shields 27. Retinal metastases - Christopher Pelzek and Andrew Schachat 28. Remote effects of cancer on the retina - Ranjit S. Dhaliwal and Andrew P. Schachat 29. Melanocytoma of the optic disc - Jerry A. Shields and Leonard Joffe
Section 2 Tumors of the Retinal Pigment Epithelium
30. Congenital hypertrophy of the retinal pigment epithelium - Helmut Buettner 31. Combined hamartoma of the retina and retinal pigment epithelium - Dean Elliott and Andrew P. Schachat
Section 3 Choroidal Melanoma and Related Issues
32. Choroidal nevi - Justin L. Gottlieb, José Alain Sahel and Daniel M. Albert 33. Epidemiology of uveal melanoma - Johanna M. Seddon and Tara A. Young 34. Choroidal melanoma: prognosis - Johanna M. Seddon and Tara A. Young 35. Pathology of choroidal melanoma - Shannath L. Merbs and W. Richard Green 36. Overview of management of posterior uveal melanoma - Jerry A. Shields 37. Enucleation for choroidal melanomas - Frederick Davidorf, Jeffrey McAdoo, Robert Chambers and Lewis Chorich 38. Brachytherapy for choroidal melanoma - Dennis M. Robertson, John D. Earle and Robert W. Kline 39. Charged-particle irradiation of uveal melanoma - Evangelos S. Gragoudas and Anne Marie Lane 40. Surgical resection of choroidal melanomas - Bertil E. Damato and Wallace S. Foulds 41. Vitreous, retinal, and choroidal biopsy - Anat Loewenstein, W. Richard Green, Diana V. Do and Julia A. Haller 42. Laser treatment of choroidal melanoma - Norbert Bornfeld and Gerasimos Anastassiou 43. Systematic evaluation and management of patients with choroidal melanoma - James Willson 44. Collaborative ocular melanoma study - Barbara S. Hawkins and Andrew P. Schachat
Section 4 Other Tumors of the Choroid
45. Choroidal metastasis - Moody D. Wharam and Andrew P. Schachat 46. Choroidal osteoma - Carol Shields, Gary Brown, Sanjay Sharma, and Jerry Shields 47. Circumscribed choroidal hemangioma - George Sanborn 48. Miscellaneous uveal tumors - David J. Wilson 49. Leukemias and lymphomas - Ranjit Dhaliwal and Andrew Schachat 50. Non-Hodgkin’s (“reticulum cell”) lymphoma - Hilel Lewis, Andrew Schachat and Arun Singh
VOLUME 2: MEDICAL RETINA
Section 1 Normal Retinal Anatomy and Function
51. Fluorescein angiography: basic principles and interpretation -Robert Johnson, Richard McDonald, Everett Ai, J. Michael Jumper, and Arthur Fu 52. Quantitative fluorescein angiography - Srinivas Sadda and Alex Walsh 53. Diagnostic indocyanine green videogiography - Christina M. Klais, Michael D. Ober, Antonio P. Ciardella, Lawrence A. Yannuzzi and Jason S. Slakter
Section 2 Pathologic Responses
54. Pathogenesis of serous detachment of the retina and pigment epithelium - Alan C. Bird 55. Steroids in Macular Disease - Carl H. Park and Glenn J. Jaffe 56. Choroidal neovascularization - Stephen J. Ryan, David R. Hinton and Toshinori Murata
Section 3 Treatment Principles
57. Management of intraocular inflammation - Narsing A. Rao
Section 4 Macular Disease
58. Epidemiology of age-related macular degeneration - Johanna M. Seddon and Clara A. Chen 59. Age changes in Bruch’s membrane and related structures - Robyn Guymer and Alan C. Bird 60. Neovascular (exudative) age-related macular degeneration -Neil M. Bressler, Susan B. Bressler and Stuart L. Fine 61. Choroidal neovascular membrane in degenerative myopia - Gisele Soubrane and Gabriele J. Coscas 62. Central serous chorioretinopathy - Christina M. Klais, Michael D. Ober, Antonio P. Ciardella and Lawrence A. Yanuzzi 63. Macular dystrophies - August F. Deutman, Carel B. Hoyng and Janneke J.C. van Lith-Verhoeven 64. Pharmacotherapyof Age-Related Macular Degeneration - Mark S. Blummenkranz and Darius M. Moshfeghi
Section 5 Retinal Vascular Diseases
65. Etiologic mechanisms in diabetic retinopathy - Robert N. Frank 66. Nonproliferative diabetic retinopathy - Emily Y. Chew and Frederick L. Ferris III 67. Proliferative diabetic retinopathy - Matthew Davis and Barbara Blodi 68. Retinal artery obstruction - Sanjay Sharma and Gary C. Brown 69. Central retinal vein occlusion - Prithvi Mruthyunjaya and Sharon Fekrat 70. Branch retinal vein occlusion - Stephen Phillips, Sharon Fekrat and Daniel Finkelstein 71. Pregnancy and retinal disease - Justin C. Brown and Janet S. Sunness 72. Preeclampsia-eclampsia syndrome - Richard R. Ober 73. Hypertension - Robert P. Murphy, Linda A. Lam and Emily Y. Chew 74. Rheumatic diseases - Jennifer E. Thorne and Douglas A. Jabs 75. Parafoveal telangiectasis - Emily Y. Chew 76. Coats’ disease - Diana V. Do and Julia A. Haller 77. Disseminated intravascular coagulopathy and related vasculopathies - James P. Bolling 78. Hemoglobinopathies - Geoffrey G. Emerson, Joseph B. Harlan Jr, Sharon Fekrat, Gerard A. Lutty and Morton F. Goldberg 79. Retinopathy of prematurity - Earl A. Palmer, Dale L. Phelps, Rand Spencer and Gerard A. Lutty 80. Acquired retinal macroaneurysms - Emily Y. Chew and Robert P. Murphy 81. Eales’ disease - Mohammed K. Barazi and Robert P. Murphy 82. Radiation retinopathy - Albert M. Maguire and Andrew P. Schachat 83. Ocular ischemic syndrome - Sanjay Sharma and Gary C. Brown 84. The Epidemiology of Diabetic Retinopathy - Ron Klein and Barbara Klein 85. Clinical Applications of Diagnostic Indocyanine Green Angiography - Nicole E. Gross and Lawrence A. Yannuzzi 86. Optical coherence tomography and retinal thickness assessment for diagnosis and management - Andrew A. Moshfeghi, Elias C. Mavrofrides and Carmen A. Puliafito 87. Retina-related clinical trials: a resource bibliography - Barbara S. Hawkins and Diana V. Do
Section 6 Inflammatory Disease
88. Ocular toxoplasmosis - Douglas A. Jabs and Quan Dong Nguyen 89. Ocular toxocariasis - CP Wilkinson 90. Cytomegalovirus infections of the retina - Jean D. Vaudaux and Gary N. Holland 91. Retinal disease in HIV-infected patients - Brian R. Kosobuki and William R. Freeman 92. Acute retinal necrosis syndrome - Jay S. Pepose and Russell N. Van Gelder 93. Endogenous fungal infections of the retina and choroid - Gary N. Holland 94. Pars planitis - Pravin U. Dugel, Derek Y. Kunimoto and Ronald E. Smith 95. Retinal syphilis and tuberculosis - David L. Knox 96. Diffuse unilateral subacute neuroretinitis - Janet L. Davis, J. Donald M. Gass, Karl R. Olsen 97. Scleral Inflammatory Disease - Albert T. Vitale and Maite Sainz de la Maza 98. Ocular histoplasmosis - Barbara Hawkins, Judith Alexander, Sharon D. Solomon and Andrew Schachat 99. Birdshot retinochoroidopathy - Stephen J. Ryan and Narsing A. Rao 100. Multifocal choroiditis with panuveitis, diffuse subretinal fibrosis and punctate inner choroidopathy - James Folk and Jonathan Walker 101. Multiple evanescent white dot syndrome - Lee M. Jampol and Linda Tsai 102. Sarcoidosis - Douglas A. Jabs and Quan Dong Nguyen 103. Acute multifocal placoid pigment epitheliopathy - Alan C. Bird 104. Serpiginous choroiditis - J. Michael Jumper, H. Richard McDonald, Robert N. Johnson, Everett Ai and Arthur D. Fu 105. Sympathetic ophthalmia - Narsing A. Rao 106. Vogt-Koyanagi-Harada Disease - P. Kumar Rao and Narsing A. Rao
Section 7 Other Diseases
107. Drug toxicity of the posterior segment - Robert A. Mittra and William F. Mieler 108. Retinal Injuries From Light: Mechanisms, Hazards And Prevention - Martin A. Mainster and Patricia L. Turner 109. Traumatic chorioretinopathies - James S. Kelley
Section 8 Optic Nerve
110. Optic disc pits and associated serous macular detachment - Alfredo A. Sadun 111. Immunosuppressive therapy for posterior segment disease - Douglas A. Jabs and Esen Karamursel Akpek
VOLUME 3: SURGICAL RETINA
Section 1 What Normally Keeps the Retina Attached? 112. Mechanisms of normal retinal adhesion - Michael F. Marmor 113. Fluid physiology of the subretinal space - Jonathan E. Pederson 114. Vitreoretinal interface - W. Richard Green and Jerry Sebag
Section 2 Retinal Reattachments: Surgical Principles and Techniques
115. Cellular effects of detachment and reattachment on the neural retina and the retinal pigment epithelium - Steven K. Fisher and Geoffrey P. Lewis 116. Pathogenic mechanisms of retinal detachment - Kean T. Oh, Mary Elizabeth Hartnett and Maurice B. Landers III 117. The effects and action of scleral buckles in the treatment of retinal detachment - John T. Thompson 118. Techniques of scleral buckling - George A. Williams and Thomas M. Aaberg, Jr 119. Pneumatic Retinopexy - Daniel A. Brinton and Eugene S. Lit 120. Primary vitrectomy in rhegmatogenous retinal detachment - Heinrich Heimann and Bernd Kirchhof 121. Optimal procedures for retinal detachments - G. William Aylward 122. Prevention of retinal detachment - C. P. Wilkinson 123. Nonrhegmatagenous retinal detachment - Rajiv Anand and William S. Tasman 124. Nonrhegmatogenous Retinal Detachment: Retinal Detachment and Retinoschisis without a Macular Hole in Highly Myopic Eyes - Masahito Ohji and Yasuo Tano 125. Principles and techniques of vitreoretinal surgery - Steve Charles 126. Management of the pupil - Jay M. Stewart and Eugene de Juan, Jr
Section 3 Special Adjuncts to Treatment
127. Intraocular gases - Stanley Chang 128. Perfluorocarbon liquids in vitreous surgery - Robert Kwun and Stanley Chang 129. Silicone oils: physicochemical properties - Jean-Marie Parel, Peter Milne, Sandrine Gautier, Valerie Jallet and Franck Villain 130. Silicone oil in vitreoretinal surgery - Ron P. Gallemore and Brooks W. McCuen II 131. The Pathogenesis of proliferative vitreoretinopathy - Peter A. Campochiaro 132. The mechanism of action of drugs for the treatment of vitreoretinal scarring - Mark S. Blumenkranz and Michael K. Hartzer 133. Vitrectomy for infectious endophthalmitis - Travis A. Meredith 134. Diagnostic and therapeutic vitrectomy for uveitis - Russell N. Van Gelder and Henry J. Kaplan
Section 4 Complicated Forms of Retinal Detachment
135. Proliferative vitreoretinopathy - John T. Thompson 136. Retinotomies and retinectomies - Gary Abrams, Enrique Garcia-Valenzuela and Sumit Nanda 137. Giant retinal tears with proliferative vitreoretinopathy - Stanley Chang and José Manuel Lopez 138. Posterior Penetrating Trauma - Stephen J. Ryan and Young Hee Yoon 139. Posterior segment manifestations of closed-globe contusion injury - Pravin U. Dugel, Peter H. Win and Richard R. Ober 140. Trauma: principles and techniques of treatment - Franco M. Recchia, Thomas Aaberg Jr and Paul Sternberg Jr 141. Intraocular neovascularization - Tara A. Young and Joan W. Miller 142. Proliferative diabetic retinopathy: principles and techniques of surgical treatment - Dean Eliott, Michael S. Lee and Gary W. Abrams 143. Control of perioperative bleeding in vitreoretinal surgery - David R. Chow and Serge de Bustros 144. Retinopathy of prematurity - Michael Trese 145. Surgical aspects of vitreoretinal disease in children - Peter Wiedemann 146. Management of combined inflammatory and rhegmatogenous retinal detachments (AIDS and ARN) - Allan E. Kreiger and Christine R. Gonzales 147. Macular epiretinal membranes - H. Richard McDonald, Robert N. Johnson, Everett Ai, J. Michael Jumper and Arthur D. Fu 148. Macular hole - Raymond N. Sjaarda and John T. Thompson 149. Surgical removal of subretinal choroidal neovascular membranes - Daniel P. Joseph, A. Jeffrey Whitehead and Matthew A. Thomas
Section 5 Vitreous Surgery: Additional Considerations
150. Surgical management of submacular hemorrhage - Henry C. Lee and Nancy M. Holekamp 151. Limited macular translocation - Gildo Y. Fujii and Eugene de Juan Jr. 152. Macular translocation with 360° peripheral retinectomy - Mark T. Cahill and Cynthia A. Toth 153. Retinal Pigment Epithelium and Photoreceptor Transplantation Frontiers - Vamsi Gullapalli, Mohamad Khodair, Hao Wang, Ilene Sugino, Marco Zarbin and Steven Madreperla 154. Artificial vision - Mark S. Humayun, Rohit R. Lakhanpal and James D. Weiland 155. Surgery for diffuse macular edema due to multiple causes, including proliferative vitreoretinopathy - Zdenek Gregor and Lyndon da Cruz